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JWH-018 Powder: JWH-018 (1-pentyl-3-(1-naphthyl)indole), also known as AM-678, is a cannabinoid that acts as a complete agonist at both the CB1 and CB2 cannabinoid receptors with little selectivity for CB2. It is used to create artificial hashish products that are legally marketed as “incense blends” in various countries because it has effects on animals that are similar to those of tetrahydrocannabinol (THC), a cannabinoid that is present in hashish.
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This substance is categorized as an analgesic drug since it is a full agonist at both CB1 and CB2 cannabinoid receptors. The analgesic effects of cannabinoid ligands, mediated by CB1 receptors, are well established in the treatment of arthritic and cancer pain as well as neuropathic pain. JWH-018 substances mirror the body’s naturally occurring endocannabinoid hormones, such as anandamide (AEA) and 2-AG, which are biologically active and may enhance or inhibit neuronal activity.
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The endocannabinoid system has been affected by several chemical substances that were created by John W. Huffman, an organic chemist at Clemson University. One such substance is JWH-018, the affinity for which, according to the study, is five times greater than that of THC for the cannabinoid (CB1) receptor. Mammalian brain and spleen tissue contain cannabinoid receptors, however, the structural details of the active sites are yet unclear.
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German pharmaceutical companies announced on December 15, 2008, that JWH-018 has been discovered to be one of the active components in at least three variants of Spice, a narcotic that has been sold illegally since 2002 in some countries while being sold as incense in others. Analysis of samples obtained four weeks after JWH-018 was banned in Germany revealed that the makers had reduced the alkyl chain by one carbon to get around the restriction.
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JWH-018 has a reported binding affinity of 9.0 5.00 nM at CB1 and 2.94 2.65 nM at CB2, making it a complete agonist of both CB1 and CB2 cannabinoid receptors. For human CB1 receptors, JWH-018 has an EC50 of 102 nM, while for human CB2 receptors, it has an EC50 of 133 nM. At zero dosages, JWH-018 causes hypothermia and bradycardia in rats. 3–3 mg/kg, indicating an active cannabinoid-like activity
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At the very least, one instance of JWH-018 dependence has been publicly published. For eight months, the customer took JWH-018 every day. The withdrawal signs and symptoms were more severe than those brought on by hashish dependence. JWH-018 has been shown to cause significant changes in CB1 receptor density after administration, causing desensitization to its effects more quickly than related cannabinoids.
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Different Names: “synthetic cannabis,” “herbal incense,” “prison weed,” JWH-073, “K2,” “SPICE,” Pentyl-3-(1-naphthyl)indole, AM 678, JWH 018, powerful new synthetic cannabinoid antagonist.